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在美国Alzheimer型痴呆(ATD)占65岁以上患病人数的11％,为最普通死因的第四或第五位,痴呆病的临床和病理特征已明瞭,但多数病因至今未明。在研究老年斑时发现矽和铝与Alzheimer氏病(AD)有联系。Crapper等发现脑组织铝含量增高,但未为其他学者证实。有文献报导一例与锰中毒引起类似锥体外系症状的AD一样的锰含量增高。锌缺乏也认为是ATD一个原因。我们测定了各种神经系统及内科疾病患者脑脊液多种微量元素,加以研究。
In the United States, Alzheimer’s dementia (ATD) accounts for 11% of patients over the age of 65, the fourth or fifth most common cause of death. The clinical and pathological features of dementia have become clear, but most of the causes remain unknown. Silica and aluminum were found to be associated with Alzheimer’s disease (AD) when studying age spots. Crapper found that brain tissue increased aluminum content, but not confirmed by other scholars. It has been reported in the literature that the same manganese content as that caused by manganese poisoning causes similar extrapyramidal symptoms. Zinc deficiency is also considered a reason for ATD. We measured a variety of neurological and cerebrovascular diseases in patients with a variety of trace elements to be studied.