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为研究ＳＹ９１４β－溶血性链球菌制剂的体外抗瘤作用及作用机制，用ＳＲＢ法对抗癌链球菌制剂ＳＹ９１４作用于人癌细胞株（ＳＧＣ－７９０１，Ａ５４９，ＴＣＡ８１１３，ＫＢ）进行体外抑瘤实验研究，并通过电镜对ＳＹ９１４作用于ＳＧＣ７９１０的过程进行超微结构观察，Ｈ３掺入实验观察ＳＹ９１４对蛋白合成的影响．结果：ＳＹ９１４对４个细胞株具有体外生长抑制作用，ＩＣ５０分别为６２１３（ＳＹ７９０１），１６１７（Ａ５４９），１１５２（ＴＣａ８１１３），１９６（ＫＢ）［ｍｇ／Ｌ］．电镜观察发现ＳＹ９１４作用于瘤细胞后、胞浆内核蛋白体数量明显减少，细胞溶解坏死，Ｈ３掺入实验提示ＳＹ９１４具有显著抑制肿瘤细胞蛋白质合成的作用．结果显示：ＳＹ９１４具有直接抑制肿瘤细胞生长的作用，其作用机制可能与蛋白质合成抑制有关
In order to study the anti-tumor effect and mechanism of SY914β-hemolytic streptococcus preparation in vitro, the anti-tumor activity of SGC-7901, A549, TCA8113 and KB cells was tested by SRB method in vitro against Streptococcus pneumoniae SY914 The effect of SY914 on the synthesis of SGC7910 was observed by electron microscopy. The effect of SY914 on protein synthesis was observed by the incorporation of H3. Results: SY914 inhibited the growth of 4 cell lines in vitro with IC50 of 62.13 (A590), 16.17 (A549), 11.52 (TCa8113) and 196 (KB) [mg / L], respectively. Electron microscopy showed that after SY914 was administered to tumor cells, the number of cytoplasmic nucleosomes decreased significantly, and cell lysis and necrosis were observed. The results of H3 incorporation suggested that SY914 could significantly inhibit the protein synthesis of tumor cells. The results showed that: SY914 has a direct inhibitory effect on tumor cell growth, the mechanism may be related to protein synthesis inhibition