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目的:探讨胎膜早破孕妇血清C-反应蛋白(CRP)和白细胞介素-1(IL-1)与胎膜早破的关系,为临床诊断治疗提供参考。方法:纳入研究的112例足月胎膜早破患者,其中足月胎膜早破未感染患者(A组)和胎膜早破合并绒毛膜羊膜炎患者(B组),各56例;选择同期在该院收诊的正常足月孕妇50例作为对照组。对比分析三组孕妇血清CRP、IL-1含量,破膜时间与血清CRP和IL-1水平变化及IL-1和CRP预测绒毛膜羊膜炎的价值。结果:B组血清CRP和IL-1含量明显高于A组和对照组,且差异具有统计学意义(P<0.05);而A组和对照组比较差异无统计学意义(P>0.05);破膜时间>12 h血清CRP和IL-1水平明显高于破膜时间≤12 h,且差异具有统计学意义(P<0.05);当血清IL-1取326 pg/ml时,敏感性为78%,特异性为86%;当血清CRP取10 mg/ml时,敏感性为73%,特异性为63%。结论:血清CRP和IL-1是诊断足月胎膜早破孕妇出现绒毛膜羊膜炎的特异、敏感指标,具有重要临床价值,值得临床进一步研究。
Objective: To investigate the relationship between serum C-reactive protein (CRP), interleukin-1 (IL-1) and premature rupture of membranes in pregnant women with premature rupture of membranes, and to provide reference for clinical diagnosis and treatment. METHODS: One hundred and twelve patients with full-term premature rupture of membranes were enrolled in this study. Among them, group A received untermfemoral premature rupture of membranes (group A) and patients with premature rupture of membranes and chorioamnionitis (group B), 56 The same period in the hospital admitted to the normal 50 pregnant women as a control group. The levels of serum CRP, IL-1, the time of rupture, the levels of serum CRP and IL-1 in the three groups of pregnant women were compared and the value of IL-1 and CRP in predicting chorioamnionitis was compared. Results: The levels of serum CRP and IL - 1 in group B were significantly higher than those in group A and control group (P <0.05). There was no significant difference between group A and control (P> 0.05). The levels of serum CRP and IL-1 in rupture time> 12 h were significantly higher than those in rupture time ≤12 h (P <0.05). When serum IL-1 was 326 pg / ml, the sensitivity was 78% with a specificity of 86%. When serum CRP was taken as 10 mg / ml, the sensitivity and specificity were 73% and 63% respectively. Conclusion: Serum CRP and IL-1 are specific and sensitive markers for diagnosing chorioamnionitis in term pregnant women with full-term premature rupture of membranes, which has important clinical value and deserves further clinical study.