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动物实验和临床研究均表明性激素与癫发作有关,比较肯定的结论认为雌激素水平升高时,可使癫发作的阈值降低,加剧癫发作;孕激素可使癫发作的阈值升高,减轻癫发作。但对雄激素与癫发作的关系了解甚少,关于雄激素与癫关系目前国内尚未见报道,国外报道它们之间的关系亦不一致。睾酮是最重要的雄激素,本文综述了睾酮的代谢和其与癫及抗癫药物之间的关系。
Animal experiments and clinical studies have shown that sex hormones and epilepsy, the more conclusive conclusion that the estrogen levels, can make the threshold of epileptic seizures, aggravating epileptic seizures; progesterone can make epilepsy threshold increased, reduce epilepsy attack. However, the relationship between androgens and epilepsy is poorly understood. There are no reports about the relationship between androgens and epilepsy in China at present, and the relationship between them is also inconsistent. Testosterone is the most important androgen, and the article reviews the metabolism of testosterone and its relationship to epileptic and antiepileptic drugs.