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子宫内膜异位症是雌激素依赖性疾病,患者的在位内膜和异位内膜均存在芳香化酶过表达现象,并认为与CYP19基因启动子Ⅱ被激活有关,前列腺素E2(PGE2),类固醇生成因子(SF-1)和DAX-1等多种活性因子参与启动子Ⅱ的调节,调控局部芳香化酶产生;同时,多种细胞因子、免疫因子及环境因素的变化,也可导致局部芳香化酶异常表达,局部雌激素生成代谢增多,而异位内膜中灭活雌二醇的17β-HSD-2减少,结果在局部造成一个雌激素高水平的微环境,这些是导致子宫内膜异位症病理发生的重要机制。
Endometriosis is an estrogen-dependent disease. Aromatase overexpression occurs in the eutopic and ectopic endometrium of patients and is thought to be related to the activation of the promoter of CYP19 gene. Prostaglandin E2 (PGE2 ), Steroidogenic factor (SF-1) and DAX-1 and other active factors involved in the regulation of promoter Ⅱ, regulating the production of local aromatase; the same time, a variety of cytokines, immune factors and environmental changes, but also Resulting in aberrant local aromatase expression, increased local estrogen production and metabolism, and decreased ectopic endometrial inactivation of estradiol 17β-HSD-2, resulting in the local production of a high level of estrogen microenvironment, which is the result of Endometriosis pathogenesis of the important mechanisms.