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采用可控开环聚合(ROP)和原子转移自由基聚合(ATRP)相结合的方法制备出一系列单甲氧基聚乙二醇-b-聚(ε-己内酯)-b-聚甲基丙烯酸-N,N-二甲氨基乙酯(MePEG-b-PCL-b-PDMAEMA).采用核磁(1H NMR)和凝胶渗透色谱(GPC)研究了聚合物的结构并对聚合物的分子量大小和分布进行了表征.聚合物的热稳定性能、结晶性能和亲水性能分别由热重分析仪(TGA)、X-衍射仪(XRD)和静态水滴接触角测定.分别采用荧光光谱法和1H NMR(以D2O为溶剂)方法研究了聚合物纳米粒子的形成.激光光散射(DLS)和透射电镜(TEM)研究结果表明聚合物纳米粒子具有球形结构,粒子大小在40～70 nm之间并且对外界环境具有pH敏感性能.MePEG-b-PCL-b-PDMAEMA纳米粒子在同时包裹带有正电荷药物以及疏水性药物方面具有潜在的应用前景.
A series of monomethoxy polyethylene glycol-b-poly (ε-caprolactone) -b-polymethacrylates were prepared by a combination of controlled ring opening polymerization (ROP) and atom transfer radical polymerization (ATRP) (MePEG-b-PCL-b-PDMAEMA). The structure of the polymer was investigated by NMR and gel permeation chromatography (GPC) Size and distribution of the polymer were characterized.The thermal stability, crystallinity and hydrophilicity of the polymer were measured by TGA, XRD and static water drop contact angle respectively.Using fluorescence spectroscopy and The formation of polymer nanoparticles was investigated by 1H NMR (D2O) method.The results of laser light scattering (DLS) and transmission electron microscopy (TEM) showed that the polymer nanoparticles had a spherical structure with particle sizes between 40 and 70 nm And has pH-sensitive properties to the external environment.MePEG-b-PCL-b-PDMAEMA nanoparticles have potential applications in the simultaneous encapsulation of positively charged drugs and hydrophobic drugs.