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目的:观察比较伊曲康唑与特比萘芬治疗甲癣的疗效、安全性与经济性。方法:随机选取趾甲癣患者分二组,A 组用伊曲康唑冲击疗法:口服伊曲康唑200㎎、每日二次、连用七日、停药三周为一疗程,重复五个疗程;B组口服特比萘芬250㎎、每日一次、连续20周。停药后48周,进行疗效评估和观察不良反应,并做二组之治疗成本分析比较。结果:A 组有43例,完全治愈29例、显效2例、无效12例,总有效率31例(72.1﹪)。不良反应为3例(6.9﹪);B组有41例,完全治愈31例,显效2例,无效8例,总有效率33例(80.5%)。不良反应4例(9.7%),不良反应主要是胃肠道反应。未见与其它药物间之交互作用。二者总有效治疗率70%以上,疗效相似。结论:口服伊曲康唑和特比萘芬治疗甲癣的疗效,安全性皆相近,是治疗趾甲癣有效而安全的治疗方法;以口服伊曲康唑较为经济。“,”Objective :To observe the efficacy ,safety and economic of itraconazole and terbinafine treatment of tinea unguium .M ethods :All patients were separated into two group randomly .A group involved the itraconazole pulse therapy :200mg orally ,twice a day ,prolonged 7 days then stopping 3 weeks for a regimen ,repeat five regimens .B group invloved continuous terbinafine 250mg orally once a day ,pro-longed 20 weeks .After discontinuation of treatment and after stopping the 48 weeks to do the final efficacy evaluation and observation of ad-verse reactions and compared the cost -effectivenese analysis .Reault :A group 43 patients ,complete cure 29 ,significant cure 2 ,invalid 12 . Therapy effectiveness 31(72 .1% ) ,Adverse reactions was 3(6 .9% );B group 41 patients ,complete cure 31 ,significant cure 2 ,invalid 8 , Therapy effectiveness 33(80 .5% ) ,Adverse reactions was 4(9 .7% ):mainly gastrointestinal side effects ,drug interactions is not found .Two goups are the same effective with 70% up therapy effectiveness .Conclusion :Itraconazole and terbinafine treatment of tinea unguium is a ef-fective and safe treatment method .Itraconazole is more economic than terbinafine w hile envelop cost -effectiveness .