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目的：观察比较伊曲康唑与特比萘芬治疗甲癣的疗效、安全性与经济性。方法：随机选取趾甲癣患者分二组，A 组用伊曲康唑冲击疗法：口服伊曲康唑200㎎、每日二次、连用七日、停药三周为一疗程，重复五个疗程；B组口服特比萘芬250㎎、每日一次、连续20周。停药后48周，进行疗效评估和观察不良反应，并做二组之治疗成本分析比较。结果：A 组有43例，完全治愈29例、显效2例、无效12例，总有效率31例（72．1﹪）。不良反应为3例（6．9﹪）；B组有41例，完全治愈31例，显效2例，无效8例，总有效率33例（80．5％）。不良反应4例（9．7％），不良反应主要是胃肠道反应。未见与其它药物间之交互作用。二者总有效治疗率70％以上，疗效相似。结论：口服伊曲康唑和特比萘芬治疗甲癣的疗效，安全性皆相近，是治疗趾甲癣有效而安全的治疗方法；以口服伊曲康唑较为经济。“,”Objective :To observe the efficacy ,safety and economic of itraconazole and terbinafine treatment of tinea unguium .M ethods :All patients were separated into two group randomly .A group involved the itraconazole pulse therapy :200mg orally ,twice a day ,prolonged 7 days then stopping 3 weeks for a regimen ,repeat five regimens .B group invloved continuous terbinafine 250mg orally once a day ,pro-longed 20 weeks .After discontinuation of treatment and after stopping the 48 weeks to do the final efficacy evaluation and observation of ad-verse reactions and compared the cost -effectivenese analysis .Reault :A group 43 patients ,complete cure 29 ,significant cure 2 ,invalid 12 . Therapy effectiveness 31(72 .1% ) ,Adverse reactions was 3(6 .9% );B group 41 patients ,complete cure 31 ,significant cure 2 ,invalid 8 , Therapy effectiveness 33(80 .5% ) ,Adverse reactions was 4(9 .7% ):mainly gastrointestinal side effects ,drug interactions is not found .Two goups are the same effective with 70% up therapy effectiveness .Conclusion :Itraconazole and terbinafine treatment of tinea unguium is a ef-fective and safe treatment method .Itraconazole is more economic than terbinafine w hile envelop cost -effectiveness .