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近来的一些研究表明,合成的维甲酸可以在体内外影响神经系统的生长和分化。一小部分病人口服合成维甲酸致中枢神经系统副作用已见于报导。这些副作用的症状包括头痛、抑郁和戒酒硫样反应,其他病例报告尚有头晕、眼球震颤危象、人格障碍和听力下降。然而,维甲酸所致的中枢神经系统副作用可能更多见于亚临床水平。由于此类影响或多或少累及脑干,本文作者研究了33例因结节囊肿性痤疮口服13-顺维甲酸患者的听力脑干反应,以验证这种化合物对突触活性和对听神经动作电位传导的影响。
Some recent studies have shown that synthetic retinoids can affect the growth and differentiation of the nervous system both in vitro and in vivo. A small number of patients oral synthesis of retinoic acid-induced central nervous system side effects have been reported. Symptoms of these side effects include headache, depression and alcohol-like reactions; other cases report dizziness, nystagmus, personality disorder, and hearing loss. However, retinoic acid-induced central nervous system side effects may be more common at subclinical levels. As these effects affect brain stem more or less, the authors studied the auditory brainstem response in 33 patients with nodular cystic acne taking oral 13-cis retinoic acid to verify the effect of this compound on synaptic activity and auditory nerve activity Effect of potential conduction.