当代医药学的发展根据分子结构原理,研制出一大类的核酸药物。天然的核苷和核苷酸是合成核酸类药物的基本原料,目前有两条生产路线,一是从酵母核糖核酸经化学法或酶法进行水解制取,可得到分别含腺嘌呤,鸟嘌呤、胞嘧啶、尿嘧啶碱基的四种核苷或四种核苷酸;二是用发酵法分别直接得到特定的核苷 The development of contemporary medicine According to the molecular structure principle, developed a large class of nucleic acid drugs. Natural nucleosides and nucleotides are the basic raw materials for the synthesis of nucleic acids. At present, there are two production routes. One is the enzymatic hydrolysis of yeast ribonucleic acid to obtain the adenine and guanine , Cytosine, uracil bases four nucleosides or four kinds of nucleotides; the second is the fermentation method directly to the specific nucleoside