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目的观察新型抗胆碱药盐酸戊乙奎醚治疗急性有机磷农药中毒(AOPP)的效果。方法将急性有机磷农药中毒患者随机分为盐酸戊乙奎醚组(试验组)和阿托品组(对照组),两组其他常规治疗方法相同,比较两组疗效。结果盐酸戊乙奎醚对不同中毒程度患者毒蕈碱样症状的控制疗效确凿,与阿托品组比较,其中毒症状消失时间、全血胆碱酯酶(ChE)活性变化时间比较差异无统计学意义(P>0.05),但两组用药次数、用药总量、不良反应发生情况比较,差异有统计学意义(P(0.05)。结论盐酸戊乙奎醚在治疗急性有机磷农药中毒时可以取代阿托品。
Objective To observe the effect of penehyclidine hydrochloride on acute organophosphorus pesticide poisoning (AOPP). Methods Acute organophosphorus pesticide poisoning patients were randomly divided into penehyclidine hydrochloride group (experimental group) and atropine group (control group). The other two conventional treatment methods were the same, and the curative effect was compared between the two groups. Results Penehyclidine hydrochloride was effective in controlling muscarinic symptoms in patients with different degrees of poisoning. Compared with atropine group, there was no significant difference in the disappearance time of toxic symptoms and the change of ChE activity (P0.05) .There was significant difference between the two groups in the number of medication, the amount of medication and the incidence of adverse reactions (P (0.05)) .Conclusion Penehyclidine hydrochloride can replace atropine in the treatment of acute organophosphorus pesticide poisoning .