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目的探讨多发性肌炎(polymyositis,PM)、皮肌炎(dermatomyositis,DM)合并间质性肺病(interstitial lung disease,ILD)患者血清Th17相关细胞因子白细胞介素(interleukin)17、白细胞介素(interleukin)22水平及临床意义。方法 50例PM/DM患者,分为ILD组和Non-ILD组,并与30例健康者对照研究。用Luminex液相芯片技术分别检测血清IL-17、IL-22水平,观察比较各组细胞因子表达情况。采用Mann-Whitney U检验进行统计结果分析。结果 (1)治疗前ILD组及Non-ILD组2组患者年龄、性别、CK、皮肤黏膜VAS评分、骨骼关节VAS评分、胃肠道VAS评分、心脏VAS评分、肌肉VAS评分的比较,差异无统计学意义(均P>0.05)。(2)治疗前血清IL-17、IL-22在PM/DM组的表达高于健康对照组,差异有统计学意义(均P<0.01),且ILD组较Non-ILD组显著增高(均P<0.01)。(3)ILD组患者治疗后血清IL-17、IL-22水平较治疗前明显下降,差异有统计学意义(均P<0.01)。结论 IL-17、IL-22可能参与了PM/DM的发病,同时在PM/DM-ILD发病过程中起重要作用;IL-17、IL-22高表达可作为PM/DM-ILD发病预测及疗效判定的重要参考指标。
Objective To investigate the relationship between serum Th17-associated cytokines interleukin 17 (IL-17) and interleukin (IL-17) in patients with polymyositis (PM), dermatomyositis (DM) and interstitial lung disease Interleukin 22 levels and clinical significance. Methods Fifty patients with PM / DM were divided into two groups: ILD group and Non-ILD group, and compared with 30 healthy controls. The serum levels of IL-17 and IL-22 were detected by Luminex liquid-phase microarray. The expression of cytokines in each group was observed and compared. Mann-Whitney U test for statistical analysis. Results (1) The difference of age, sex, CK, mucocutaneous VAS score, skeletal joint VAS score, gastrointestinal VAS score, heart VAS score and muscle VAS score between the two groups before ILD and Non-ILD were no difference Statistical significance (all P> 0.05). (2) The levels of IL-17 and IL-22 in the PM / DM group before treatment were significantly higher than those in the healthy control group (all P <0.01), and were significantly higher in the ILD group than in the Non-ILD group P <0.01). (3) The levels of IL-17 and IL-22 in ILD group were significantly lower than those before treatment (all P <0.01). IL-17 and IL-22 may be involved in the pathogenesis of PM / DM and play an important role in the pathogenesis of PM / DM-ILD. Curative effect of the important reference indicators.