最近的研究表明,即使病毒基因组仅发生细微的改变,病毒进入细胞甚至同一种细胞时,使用的受体也会发生相应的变化。病毒特异性受体的演化是多种因素共同作用的结果,包括:病毒致病机制、病毒的宿主范围、病毒介导的基因靶向性、器官移植与异种移植后的病毒适应以及病毒性疾病的发生等等。对病毒特异性受体演化的研究,将深化人类对病毒性疾病的认识和探索有效的预防、控制和治疗疾病的方法。 Recent studies have shown that even with minor changes in the viral genome, the receptors used vary as the virus enters the cell or even into the same cell. The evolution of virus-specific receptors is a result of a combination of factors, including the pathogenic mechanism of the virus, the host range of the virus, gene targeting mediated by the virus, virus adaptation after organ and xenotransplantation, and viral diseases And so on. Research on the evolution of virus-specific receptors will deepen human’s understanding of viral diseases and explore effective ways to prevent, control and cure diseases.