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目的探讨硫酸氢氯吡格雷联合阿托伐他汀钙治疗老年不稳定型心绞痛的临床疗效。方法选取2014年9月—2015年9月海南医学院附属医院收治的老年不稳定型心绞痛患者116例,随机分为对照组和观察组,各58例。对照组患者单纯口服阿托伐他汀钙,观察组患者联合口服硫酸氢氯吡格雷和阿托伐他汀钙,两组患者均连续治疗两周。比较两组患者的临床疗效以及治疗前后的血脂指标、心绞痛发作频次、心绞痛持续时间。结果观察组患者的临床疗效优于对照组(P<0.05)。治疗前两组患者血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平比较,差异无统计学意义(P>0.05);治疗后观察组患者血清TC、TG、LDL-C水平低于对照组,血清HDL-C水平高于对照组(P<0.05)。治疗前两组患者心绞痛发作频次和持续时间比较,差异无统计学意义(P>0.05);治疗后,观察组患者心绞痛发作频次少于对照组,持续时间短于对照组(P<0.05)。结论硫酸氢氯吡格雷联合阿托伐他汀钙治疗不稳定型心绞痛的临床疗效确切,可有效改善患者的血脂指标和心绞痛发作情况。
Objective To investigate the clinical efficacy of clopidogrel hydrogen sulfate plus atorvastatin calcium in the treatment of unstable angina in the elderly. Methods A total of 116 elderly patients with unstable angina pectoris admitted to the Affiliated Hospital of Hainan Medical University from September 2014 to September 2015 were randomly divided into control group and observation group, 58 cases each. Patients in the control group were treated with atorvastatin calcium alone. Patients in the observation group were given oral clopidogrel hydrogen sulphate and atorvastatin calcium orally, and both groups were treated continuously for two weeks. The clinical effects of the two groups were compared before and after treatment, blood lipids, angina frequency and duration of angina pectoris. Results The clinical efficacy of the observation group was better than that of the control group (P <0.05). There was no significant difference in serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) > 0.05). After treatment, the levels of serum TC, TG and LDL-C in the observation group were lower than those in the control group, and the levels of serum HDL-C in the observation group were higher than those in the control group (P <0.05). Before treatment, the frequency and duration of angina pectoris in the two groups were not significantly different (P> 0.05). After treatment, the frequency of angina pectoris in observation group was less than that in control group, and the duration was shorter than that in control group (P <0.05). Conclusion Clinical efficacy of clopidogrel bisulfate combined with atorvastatin calcium in the treatment of unstable angina pectoris is exact, which can effectively improve the patients’ serum lipids and angina pectoris.