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具有免疫抑制活性的滋养层β-球蛋白(trophoblastic α_1-glycopratein,TBG)、胎盘α微球蛋白(placental α-microglobulins,PAMG-1、PAMG-2)作为胎儿抗原在母体免疫应答调解的复杂系统中起着重大作用。为研究不同严重程度妊高征患者胎盘蛋白同免疫活性细胞相互作用的机理,168例妊娠28～40周妇女纳入研究,其中正常孕妇45例(对照组),妊高征123例(观察组)。用阶度高速离心法分离出单核
Trophoblastic α_1-glycopratein (TBG) and placental α-microglobulins (PAMG-1, PAMG-2) have immunosuppressive activities as a complex system for the mediation of fetal immune response in fetal antigens Plays a significant role. To investigate the mechanism of placental protein interaction with immunocompetent cells in patients with different severity of PIH, 168 pregnant women with gestational age from 28 to 40 weeks were enrolled in this study. Among them, 45 cases of normal pregnant women (control group) and 123 cases of PIH (observation group) . The mononuclear cells were isolated by high-speed centrifugation