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目的:探讨子宫颈酸性磷酸酶(cervical acid phosphatase,CAP)在子宫颈癌早期诊断中的意义。方法:用Mark-PAP试剂盒免疫组织化学染色法检测CAP蛋白在350例行常规妇科体检子宫颈组织细胞中的表达,细胞内出现红色沉淀即为CAP阳性,并与液基薄层细胞检测(TCT)确诊结果进行比较。结果:CAP在子宫颈癌患者组织细胞中阳性表达,而正常的子宫颈上皮细胞及炎症细胞中无CAP表达,CAP检测结果与TCT检测确诊结果一致。结论:CAP在子宫颈癌早期诊断中可能具有指导意义。
Objective: To investigate the significance of cervical acid phosphatase (CAP) in the early diagnosis of cervical cancer. Methods: The expression of CAP protein was detected by Mark-PAP immunohistochemical staining in 350 cases of cervical gynecological examination. The red precipitate in the cells was CAP positive, TCT) confirmed the results were compared. Results: CAP was positively expressed in cervical cancer cells and no CAP was found in normal cervical epithelial cells and inflammatory cells. The results of CAP test and TCT test were consistent. Conclusion: CAP may be instructive in the early diagnosis of cervical cancer.