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目的:分析妊娠中期羊水染色体检查的临床特征及实际意义.方法:研究中纳入对象600例胎儿染色体病高危孕妇,对其均行羊膜腔穿刺羊水染色体检查.结果:600例孕妇妊娠中期行羊水穿刺检出染色体异常几率为3.2％(19/600),其中数目异常10例(52.6％)、结构异常9例(47.4％);不同的羊水穿刺指征孕妇行临床染色体检查结果存在一定差异,其中平衡易位携带者经羊水穿刺检出染色体异常率最高(47.4％).结论:临床医生接诊存在母体血清筛查阳性、高龄以及超声检查异常等情况的孕妇后,应根据其相关资料综合判断后确定是否行妊娠中期羊水染色体检查,此举对检出胎儿异常几率、降低出生缺陷率均具有重要价值.","Objective To analyze the clinical characteristics and practical significance of amniotic fluid chromosome examination in the middle of pregnancy. Methods 600 pregnant women with high risk of fetal chromosomal disease were included in the study. All the amniocentesis amniotic fluid chromosomes were performed on them. Results 600 cases of second trimester pregnant women undergoing amniocentesis detection of chromosomal abnormalities occurring in 3.2％ (19/600), in which the number of abnormal 10 cases (52.6％), 9 cases of abnormal structure (47.4％); amniocentesis different indications of pregnant women underwent clinical examination of chromosome results in some differences, the balanced translocation by amniocentesis were highest abnormal chromosome the rate (47.4％). Condusion The existence of mateal serum screening clinicians admissions positive, age and ultrasound abnormalities in pregnant women, should be based on the relevant information to determine whether the judgment for the mid pregnancy amniotic fluid chromosome, this detection of fetal abnormalities and reduce the risk of birth defects rate is of important value.