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目的观察临床中应用氨氯地平治疗高血压病合并心房颤动患者的疗效。方法 180例老年高血压病合并心房颤动(简称房颤)患者进行研究,随机分为治疗组和对照组,每组90例。对照组给予缬沙坦治疗,治疗组给予氨氯地平治疗,治疗1年后,检测分析观察两组患者高血压控制情况、房颤的复发次数、复发持续时间及左心房内径的影响。结果治疗1年后随访发现,两组的收缩压(SBP)、舒张压(DBP)、P波离散度(Pd)、左心房内径(LAD)、高敏C-反应蛋白(hs-CRP)及脑钠肽(BNP)相关指标都取得了显著的效果(P<0.05);其中对照组房颤复发率为27.77%,治疗组组为31.15%,两组比较差异无统计学意义(P>0.05)。结论对于高血压合并阵发性心房颤动患者,使用缬沙坦或氨氯地平都可以起到较好的防治效果。
Objective To observe the clinical efficacy of amlodipine in the treatment of patients with hypertension and atrial fibrillation. Methods A total of 180 elderly hypertensive patients with atrial fibrillation (AF) were studied and randomly divided into treatment group and control group, with 90 cases in each group. The control group was treated with valsartan. The treatment group was treated with amlodipine. After 1 year of treatment, the blood pressure control, the frequency of recurrence of atrial fibrillation, the duration of recurrence and the diameter of the left atrium were observed and analyzed. Results One year after treatment, SBP, DBP, Pd, LAD, hs-CRP, (P <0.05). The recurrence rate of atrial fibrillation was 27.77% in the control group and 31.15% in the treatment group, there was no significant difference between the two groups (P> 0.05) . Conclusions Valsartan or amlodipine may play a good preventive and therapeutic effect in patients with hypertension and paroxysmal atrial fibrillation.