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模式生物在生命科学研究中发挥着核心作用,缺乏成熟的药用模式生物研究体系已成为阻碍天然药物生物合成研究发展的重要瓶颈.灵芝是目前研究最深入的药用生物之一,具有模式生物的鲜明特征:世代短、子代多、基因组小、培养条件简单、可进行遗传转化、对人体和环境无害等.灵芝多元化的次生代谢途径使其成为研究天然药物生物合成及其调控的理想模式生物.近期,全基因组序列的测定完成为灵芝成为模式生物奠定了坚实的基础.作为药用模式真菌,灵芝将在次生代谢产物多样性研究、药用真菌发育生物学及天然药物合成生物学等领域发挥重要作用.同时,推广灵芝成为一种新的模式生物将有利于整合现代生命科学的前沿技术和研究策略,进而深入阐明次生代谢研究领域中具有普遍性的机制和规律,为建设高效可控的天然药物合成平台奠定基础.
Model organism plays a central role in life science research, and the lack of a mature system of medicinal model biological research has become an important bottleneck hindering the development of natural medicine biosynthesis.Ganoderma lucidum is one of the most in-depth study of medicinal organisms, with model organisms Of the distinctive features: short generation, offspring, small genome, simple culture conditions, genetic transformation can be carried out, harmless to the human body and the environment, etc. Ganoderma multiplex secondary metabolic pathway to become a natural medicine biosynthesis research and regulation Of the ideal model organisms recently completed the determination of the complete genome sequence for the Ganoderma lucidum to become a model organism laid a solid foundation as a medicinal fungi, Ganoderma lucidum will be in the secondary metabolites diversity, medicinal fungal developmental biology and natural medicine Synthetic biology, etc. At the same time, the promotion of Ganoderma lucidum as a new model organism will be conducive to the integration of cutting-edge technologies and research strategies in modern life sciences, and further clarify the mechanisms and laws prevailing in the field of secondary metabolites research , Laying the foundation for the construction of an efficient and controllable natural medicine synthesis platform.