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对甘草甜素（ＧＬ）抑制二乙基亚硝胺（ＤＥＮ）诱发大鼠肝癌前病变γ－谷氨酰转肽酶（ＧＧＴ）阳性灶发生的时间－效应关系进行了研究，并用体视学方法进行计量分析。结果显示，①在诱癌的启动期和促进期持续给予ＧＬ的实验组，其ＧＧＴ阳性灶的面数密度、平均截面积和体密度分别明显低于对照组（Ｐ＜０．０１）；②仅在启动期给ＧＬ的组和仅在促进期给ＧＬ的组也都有一定的抑制作用，但前者强于后者。提示ＧＬ对ＤＥＮ致癌的启动期和促进期都有抑制作用。
To investigate the time-response relationship of glycyrrhizin (GL) inhibition of diethylnitrosamine (DEN)-induced gamma-glutamyl transpeptidase (GGT) positive lesions in rat precancerous lesions, and to use stereology Methods for quantitative analysis. The results showed that 1 the number density, average cross-sectional area and body density of GGT-positive foci were significantly lower in the experimental group with continuous administration of GL than in the control group (P<0.01). Only the group given GL at the start-up period and the group given GL only at the prolongation period had a certain inhibitory effect, but the former was stronger than the latter. It is suggested that GL has an inhibitory effect on the initiation phase and promotion phase of DEN carcinogenesis.