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目的：探讨大肠疾病形态计量学和凋亡规律。方法：应用图像自动分析系统，检测了大肠疾病形态计量学参数和凋亡指数（AI）。结果：大肠腺癌AI明显高于大肠腺瘤和炎性增生组（P分别＜O．05和＜O．001）；细胞核面积、周长、凸状周长、等效直径、周长面积因子和核平均灰度六项参数，在腺癌组明显高于腺瘤和炎性增生，而灰度标准差明显低于其他两组，大肠腺癌AI与PM2／A相关系数为O．51（P＜0．05）。结论：形态计量学参数和凋亡指数在鉴别大肠疾病中具有一定参考价值。
Objective: To investigate the morphometrics and apoptosis of large intestine diseases. METHODS: Morphometric parameters and apoptotic index (AI) of large intestine disease were detected using an automated image analysis system. Results: The colorectal adenocarcinoma AI was significantly higher than the colorectal adenoma and inflammatory hyperplasia group (P<0.05 and <0.001, respectively); nuclear area, perimeter, convex perimeter, equivalent diameter, perimeter area factor And the six parameters of nuclear average gray level in the adenocarcinoma group were significantly higher than adenoma and inflammatory hyperplasia, and the gray standard deviation was significantly lower than the other two groups, the colorectal adenocarcinoma AI and PM2/A correlation coefficient was O. 51 (P<0.05). Conclusion: The morphometric parameters and apoptotic index have certain reference value in the differential diagnosis of large intestine diseases.