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目的 探讨NVP(主要穹窿蛋白)在口咽鳞癌中的表达及与口咽鳞癌临床病理特征和预后的关系.方法 回顾分析73例口咽鳞癌临床病理资料,免疫组化法检测MVP表达,分析MVP表达与口咽鳞癌临床病理及预后的相关性.结果 MVP在口咽鳞癌组织中表达阳性率为67.1％,MVP表达阳性患者颈部淋巴结转移率较MVP表达阴性患者高,差异有显著性(P＜0.05).本组病例总体5年生存率为24.2％,MVP表达阳性和阴性患者5年生存率分别为6％和51.7％,差异有显著性(P＜0.001),MVP表达与口咽癌病理分化,年龄,性别和T分期无相关性,多因素分析显示MVP表达是口咽鳞癌独立预后因素(P ＜0.001).结论 MVP在口咽鳞癌中表达水平较高,MVP表达阳性口咽鳞癌患者颈部淋巴结转移风险升高,MVP表达可以作为口咽鳞癌患者预后的预测指标.“,”Objective To investigate the expression of major vault protein(MVP) in oropharyngeal squamous cell carcinoma (OSCC)tissues and analysis its relation to clinicopathologic factors and its role in predicting clinical prognosis of OSCC.Methods The data of 73 OSCC cases suffering from oropharyngeal cancer were retrospectively analyzed,and the correlation of MVP expression with the pathology and prognosis was also evaluated.The MVP expression determined with immunohistochemistry.Results Positive expression of MVP was found in 64.2％ OSCC cases,the positive rate of MVP in OSCC patients with lymph node involvement was higher than that without lymph node metastasis,showing a significant difference (P＜0.05).The total 5-year survival rate was 24.2％ in the cohort,and the 5-year survival rate was 51.7％ in patients with negative MVP expression and 6％ in the positive respectively,also showing a significant difference (P＜0.01).No significant correlation was observed between MVP expression and differentiation,T staging,age and genders.Multivariate analysis indicated MVP remained a highly significant independent prognostic factor for clinical outcome (P＜0.001).Conclusion MVP expression enhance the hazard of lymph node metastasis in OSCC,and can be regarded as an independent marker to predict sensitivity of chemotherapy or radiotherapy and prognosis of OSCC.