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目的探讨研究TB-IGRA检测在临床结核病诊断中的应用价值。方法收集2015年4月~2016年4月进行TB-IGRA检测的住院患者共414例,查询患者临床资料,分为2组,结核病组71例(其中肺内结核42例,肺外结核29例),非结核病组343例,采用SPSS 19.0统计学软件进行数据处理。结果结核病组TB-IGRA的阳性率为90.1%,明显高于非结核病组,差异有统计学意义(P<0.05),肺内结核TB-IGRA检测阳性率(88.1%)与肺外结核TB-IGRA检测阳性率(93.1%)比较,差异无统计学意义(P>0.05);陈旧性结核TB-IGRA检测阳性率(80.0%)与非陈旧性结核TB-IGRA检测阳性率(90.9%)比较,差异无统计学意义(P>0.05);TB-IGRA敏感性(90.1%)、特异性(70.6%)、阳性预测值(38.1%)、阴性预测值(97.1%)。结论 IGRA-ELISA法在筛查结核分枝杆菌感染表现出良好的敏感性,临床可以根据具体的情况来辅助诊断和鉴别诊断,具有较好的临床使用意义,敏感度为90.1%,阴性预测值较高(97.1%),做排除性诊断的意义较诊断的意义大。
Objective To explore the value of TB-IGRA in the diagnosis of clinical tuberculosis. Methods A total of 414 hospitalized patients with TB-IGRA were collected from April 2015 to April 2016. Clinical data of the patients were divided into two groups, 71 cases of tuberculosis (including 42 cases of pulmonary tuberculosis and 29 cases of extrapulmonary tuberculosis) ), Non-tuberculosis group of 343 cases, using SPSS 19.0 statistical software for data processing. Results The positive rate of TB-IGRA in tuberculosis was 90.1%, which was significantly higher than that in non-tuberculosis (P <0.05). The positive rate of TB-IGRA in tuberculosis was 88.1% The positive rate of TB-IGRA in old tuberculosis (80.0%) was significantly higher than that of non-old tuberculosis TB-IGRA (90.9%) in IGBC patients (93.1%) (P> 0.05) (P> 0.05). TB-IGRA sensitivity (90.1%), specificity (70.6%), positive predictive value (38.1%) and negative predictive value (97.1%) were significantly different between the two groups. Conclusion IGRA-ELISA method has a good sensitivity in the screening of Mycobacterium tuberculosis infection. Clinical diagnosis and differential diagnosis can be assisted according to the specific conditions. It has a good clinical significance, with a sensitivity of 90.1% and a negative predictive value The higher (97.1%), the meaning of exclusion diagnosis than the significance of diagnosis.