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目的：研究转化生长因子β＿１（ＴＧＦ－β＿１）与病毒性肝炎肝纤维化发生的关系。方法：对５４例病毒性肝炎肝组织进行ＴＧＦ－β＿１以及α－平滑肌肌动蛋白（α－ＳＭＡ）、Ⅳ型胶原（Ⅳ－Ｃ）免疫组织化学研究，并检测其中４９例血清Ⅲ型前胶原肽（ＰⅢＰ）、层粘蛋白（ＬＮ）、透明质酸（ＨＡ）、Ⅳ－Ｃ等。结果：随着肝纤维化程度的加重，ＴＧＦ－β＿１在肝组织中的表达逐渐明显。在慢性肝炎重度、肝硬变慢性重型肝炎中的表达强度明显高于慢性肝炎中度、轻度及急性肝炎。同时ＴＧＦ－β＿１在肝组织中的表达与血清ＰⅢＰ、ＬＮ、ＨＡ、Ⅳ－Ｃ以及α－ＳＭＡ和Ⅳ－Ｃ在肝组织中的表达呈明显的正相关。结论：ＴＧＦ－β＿１通过刺激贮脂细胞，大量合成细胞外间质，最终导致肝脏的纤维化。
Objective: To investigate the relationship between transforming growth factor-β1 (TGF-β_1) and hepatic fibrosis in viral hepatitis. Methods: Immunohistochemical studies of TGF-β 1, α-SMA and Ⅳ-C were performed in 54 patients with viral hepatitis and 49 cases of serum type Ⅲ procollagen Peptide (PⅢP), laminin (LN), hyaluronic acid (HA), Ⅳ-C and the like. Results: With the aggravation of liver fibrosis, the expression of TGF-β 1 gradually became obvious in the liver. In chronic severe hepatitis, cirrhosis of chronic severe hepatitis expression intensity was significantly higher than the chronic hepatitis, mild and acute hepatitis. Meanwhile, the expression of TGF-β 1 in liver tissue was positively correlated with the expression of PⅢP, LN, HA, Ⅳ-C, α-SMA and Ⅳ-C in liver tissue. Conclusion: TGF-β 1 can stimulate the storage of fat-storing cells and synthesize a large amount of extracellular matrix, eventually leading to hepatic fibrosis.