近年来,由于对喘息的发病机理有了新的认识,平喘药的研究亦从单纯着眼于支气管扩张作用,发展到多作用环节研究。新型的平喘药已不断出现。现综述于下。 (一)拟肾上腺素药多数具有松弛支气平管滑肌的作用。支气管平滑肌的张力是受肌细胞内环磷腺甙与环磷鸟甙的比值(CAMP/CGMP)调节的。本类药物能兴奋β肾上腺素受体,从而激活支气管平滑肌细胞、肥大细胞和嗜碱细胞等细胞,膜上腺甙酸环化酶,后者又催化细胞内CAMP的合成。CAMP水平提高对支气管平滑肌有稳定膜电位、扩张支气管的作用。CAMP还对肥大细胞等的胞膜有稳定作用,可抑制组胺、慢反应物质当过敏 In recent years, due to the new understanding of the pathogenesis of wheezing, the study of antiasthmatic drugs from a simple focus on the role of bronchiectasis, the development of multi-role research. New antiasthmatic drugs have been emerging. Now summarized in the next. (A) the majority of adrenergic drugs with bronchial smooth muscle smoothing effect. The tension of bronchial smooth muscle is regulated by the ratio of cyclic adenosine monophosphate to cyclic guanosine (CAMP / CGMP) in the muscle cells. The class of drugs can be excited beta adrenergic receptors, thereby activating bronchial smooth muscle cells, mast cells and basophils and other cells, membrane adenylate cyclase, which in turn catalyze the synthesis of intracellular CAMP. CAMP level increased bronchial smooth muscle membrane potential stability, the expansion of the role of the bronchus. CAMP also has a stabilizing effect on the membrane of mast cells and the like, and can inhibit histamine and slow-acting substances when allergic