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比较野生和人工繁育树鼩的部分生理指标,为人类疾病的动物模型创制提供基本参数。血液采自昆明地区54只野生树鼩(被捕获后人工饲养1—2月)和54只子一代人工繁育树鼩。该研究首次报道在两组动物中,肌酸激酶、肌钙蛋白I、总胆汁酸、果糖胺、低密度脂蛋白胆固醇等在性别间差异无显著性;这些指标在人工繁育树鼩中的中位数(四分位数间距)依次为:1449(956)U/L、5.94(7.23)μg/L、15.6(19.7)μmol/L、393.5(80.8)μmol/L和0.36(0.32)mmol/L;在野生树鼩中依次为:986(564)U/L、4.01(4.10)μg/L、20.0(20.6)μmol/L、379.0(104.0)μmol/L和0.46(0.23)mmol/L。人工繁育树鼩生理指标表现出个体间离散程度降低趋势,但个别反映肝脏功能及心肌情况的指标表现出平均值上升,个体离散程度扩大的现象。这些生理指标为人类疾病的树鼩模型创制打下了基础。
The comparison of some physiological indexes of wild and artificial breeding tree trunks provides the basic parameters for the creation of animal models of human diseases. Blood was collected from 54 wild tree trunks in Kunming (1-2 months after catching) and 54 sub-generations of artificial tree trunks. This study was first reported in two groups of animals, creatine kinase, troponin I, total bile acid, fructosamine, low density lipoprotein cholesterol and other gender differences were not significant; these indicators in artificial breeding tree shrew in The median of interquartile range was 1449 (956) U / L, 5.94 (7.23) μg / L, 15.6 (19.7) μmol / L, 393.5 (80.8) μmol / L and 0.36 (0.32) mmol / L, and the wild tree shrews were 986 (564) U / L, 4.01 (4.10) μg / L, 20.0 (20.6) μmol / L, 379.0 (104.0) μmol / L and 0.46 (0.23) mmol / L respectively. Physiological indexes of artificial breeding tree shrews showed a tendency of decreasing discrete degree among individuals, but individual indexes reflecting liver function and myocardial condition showed an average increase and an individual discrete degree increased. These physiological indicators laid the foundation for the creation of a tree-tree model of human disease.