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目的:设计合成一种新的红景天苷(salidroside,SDS)类似物—酪醇半乳糖苷(tyrosol galactoside,TG),进一步探讨其对心脑的保护作用并与红景天苷的保护作用进行比较。方法:实验分为两个部分:分别采用大鼠大脑中动脉闭塞(MCAO)模型和大鼠心肌缺血/再灌注(I/R)模型,通过神经功能评分(NBS)和TTC染色,评价两者(SDS和TG)的脑保护功能。通过左室收缩压(LVSP)、左室等容收缩/舒张期压力上升或下降最大速率(±dp/dtmax)、血清中肌酸激酶(CK)的活性和丙二醛(MDA)的水平评价两者的心脏保护功能。结果:TG和SDS均能显著改善大鼠局灶性脑I/R损伤NBS,减少脑梗死容积,但二者无统计学差异。与SDS相比较,TG组的LVSP和±dp/dtmax显著提高(P<0.05),血清中CK的活性和MDA的浓度也显著降低(P<0.01)。结论:TG和SDS均具有明显的心脑保护作用,但前者的心肌保护作用强于后者。
OBJECTIVE: To design and synthesize a new analogue of salidroside (SDS), tyrosol galactoside (TG), to further explore its protective effect on cardiocerebral and brain and protect it from salidroside Compare. Methods: The experiment was divided into two parts: the model of middle cerebral artery occlusion (MCAO) and the model of myocardial ischemia / reperfusion (I / R) in rats were established respectively. The neurological function score (NBS) (SDS and TG) of brain protection function. Serum creatine kinase (CK) activity and malondialdehyde (MDA) levels were assessed by left ventricular systolic pressure (LVSP), left ventricular isovolumic / diastolic pressure rise or drop maximum rate (± dp / dtmax) Both have heart protection. Results: Both TG and SDS could significantly improve the focal cerebral I / R injury in rats and decrease the volume of cerebral infarction, but there was no significant difference between them. Compared with SDS, LVSP and ± dp / dtmax in TG group were significantly increased (P <0.05), serum CK activity and MDA concentration were significantly decreased (P <0.01). Conclusion: Both TG and SDS have significant cardioprotection, but the former is more protective than the latter.