论文部分内容阅读
目的:比较观察子痫前期与正常妊娠患者血小板相关血栓前状态(PTS)分子标志物水平。方法:选择子痫前期妊娠晚期24例,分为轻度子痫前期组11例和重度子痫前期组13例;另外选择正常妊娠晚期(正常组)20例。所有病例均于入院后空腹抽取静脉血,分离血浆,采用酶联免疫吸附试验(ELISA)方法,严格按照试剂盒说明书,检测血栓烷B2(TXB2)、血小板α颗粒膜蛋白(GMP-140)及血管性血友病因子(vWF)水平。结果:重度子痫前期组TXB2、vWF及GMP-140水平均显著高于轻度子痫前期组(P<0.05),非常显著高于正常组(P<0.01)。轻度子痫前期组TXB2、vWF及GMP-140水平与正常组比较,均差异不显著(P>0.05)。结论:子痫前期妊娠晚期患者血小板相关PTS分子标志物水平较正常妊娠晚期患者显著升高,其存在PTS。
Objective: To compare the levels of platelet-related prethrombosis (PTS) markers in preeclampsia and normal pregnancy. Methods: Twenty-four pregnant women with preeclampsia were divided into three groups: mild preeclampsia group (n = 11) and severe preeclampsia group (n = 13). Another 20 normal pregnant women (n = 20) were selected. All patients were admitted to hospital on an empty stomach after venous blood was drawn and plasma was separated. Thromboxane B2 (TXB2) and platelet α-granule membrane protein (GMP-140) were detected by enzyme linked immunosorbent assay (ELISA) Vascular hemophilia factor (vWF) levels. Results: The levels of TXB2, vWF and GMP-140 in severe preeclampsia group were significantly higher than those in mild preeclampsia group (P <0.05), and significantly higher than those in normal group (P <0.01). The levels of TXB2, vWF and GMP-140 in mild preeclampsia group were not significantly different from those in normal group (P> 0.05). CONCLUSIONS: The levels of platelet-associated PTS markers in patients with preeclampsia during the third trimester of pregnancy are significantly higher than those in the normal third trimester of pregnancy with PTS present.