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据研究,核糖核酸酶能抑制核糖核酸合成和RNA病毒(如流感、口蹄疫和蜱传脑炎病毒)的繁殖。由此促进临床上研究应用核糖核酸酶治疗蜱传脑炎及其他病毒感染性疾病。1965至1971年,作者在苏联的4个流行区将507例经血清学证实的蜱传脑炎(即森林脑炎)分为两组接受不同的治疗:甲组(核糖核酸酶组)246例。应用核糖核酸酶(由牛胰腺所提取,每克含7×10~6单位)30毫克肌注,每4小时一次,共4～6天(体温正常后2天停药)。乙组(球蛋白组)261例。用抗脑炎丙种球蛋白6毫升肌注,每日1次,共3天。对症治疗两组相同。
According to research, ribonuclease inhibits RNA synthesis and RNA virus (such as influenza, foot and mouth disease and tick-borne encephalitis virus) reproduction. Thus promoting the clinical application of ribonuclease treatment of tick-borne encephalitis and other viral infectious diseases. From 1965 to 1971, the authors divided 507 seropositive tick-borne encephalitis (ie, forest encephalitis) in four popular areas in the Soviet Union into two groups for different treatment: group A (ribonuclease group) with 246 cases . Application of ribonuclease (extracted from the bovine pancreas, each containing 7 × 10 ~ 6 units) 30 mg intramuscular injection, once every 4 hours, a total of 4 to 6 days (body temperature normal after 2 days withdrawal). Group B (globulin group) 261 cases. With anti-encephalitis Ig globulin 6 ml intramuscularly, 1 day, a total of 3 days. Symptomatic treatment of the same two groups.