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幽门螺杆菌（ＨＰ）具有较高的尿素酶活性，生存在胃内，通过其特异性内毒素和对宿主的免疫反应损伤胃十二指肠粘膜。其与许多胃十二指肠疾病的关系已经明确，许多根除ＨＰ的疗法已经试用。日本胃肠病协会为了实行根除ＨＰ判断指标的标准化，提出了ＨＰ临床研究的规范。对于ＨＰ诊断，我们发展了一种新方法──竞争ＰＣＲ用于检测ＨＰ，该法是对常规ＰＣＲ的改进，可定量测定ＨＰ，亦可解决常规ＰＣＲ中有时出现的假阴性和假阳性问题。
Helicobacter pylori (HP) has a high urease activity and lives in the stomach, injuring the gastroduodenal mucosa through its specific endotoxin and immune response to the host. Its relationship with many gastroduodenal diseases has been well established and many therapies that eradicate HP have been tried. Japanese Association of Gastroenterology in order to implement the standardization of indicators to determine the eradication of HP, put forward the clinical norms of HP. For HP diagnostics, we developed a new method, competition PCR for the detection of HP, which is an improvement over conventional PCR for the quantification of HP, as well as for the occasional false-negative and false-positive problems of conventional PCR.