比较研究乳糖化人生长激素 (h GH- L )和人生长激素 (h GH )在小鼠体内药代动力学特征 ,为 h GH- L替代 h GH作为提高治疗侏儒症疗效的可能性提供依据。给小鼠静脉注射 h GH- L后定时取血和肝样 ,用 RIA技术测定血药浓度和肝药浓度 ,然后根据血药浓度 -时间曲线和肝药浓度 -时间曲线分析得出药代动力学参数 ,并与h GH对比研究。结果显示 :h GH- L 的血药浓度 -时间曲线下面积 (AU C为 32 6 86 .9)和在血清的平均驻留时间(MRT为 2 1 .37分钟 )均小于 h GH(AU C为 36 91 3.0 8,MRT为 2 4.98分钟 ) ,表明其在血液的分布量小于 h GH、清除快于 h GH;靶器官肝脏的 h GH- L分布半减期 t1 /2α为 1 .84分钟 ,消除半减期 t1 /2β为 1 1 .0 9分钟 ,肝药浓度 -时间曲线 AUC为 1 76 2 1 .9,而 h GH的 t1 /2α为 2 .1 1分钟 ,t1 /2β为 75 .6 5分钟 ,AU C为 1 2 1 4 8.2 ,表明 h GH- L的肝摄取量大于 h GH,而肝分布和清除均快于 h GH。因此 ,h GH- L 的药代动力学特征明显优于 h GH,可望成为提高治疗侏儒症疗效的药物 A comparative study of the pharmacokinetic characteristics of hGH-h and hGH in mice provides a basis for hGH-L replacement hGH as a potential for improving the efficacy of treatment of dwarfism . The mice were injected intravenously with h GH- L and then blood and liver samples were taken periodically. The plasma concentration and hepatic drug concentration were determined by RIA, and then the pharmacokinetics were determined by the plasma concentration-time curve and the hepatic drug concentration-time curve Learning parameters, and compared with h GH study. The results showed that the area under the plasma concentration-time curve for hGH-L (AU6 = 32 6 86.9) and mean residence time in serum (MRT = 21.37 min) were less than hGH (AU C 36 361 3.08, and MRT was 2. 4.98 min), indicating that the distribution in the blood was less than h GH and faster than h GH. The half-time t1 / 2α of h GH- L distribution in the liver of target organs was 1.84 minutes , The elimination of half-time t1 / 2β was 119.0 minutes, liver drug concentration-time curve AUC was 1 76 2 1 .9, and h GH t1 / 2α was 2.1 1 minutes, t1 / 2β 75 .6 5 min, AU C was 1 2 1 4 8.2, indicating that liver uptake of h GH- L was greater than h GH and liver distribution and clearance were faster than h GH. Therefore, the pharmacokinetic profile of h GH- L is significantly better than h GH, which is expected to be a drug that enhances the efficacy of treatment of dwarfism