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[目的]观察在以《抗菌药物临床应用指导原则》和《卫生部办公厅关于进一步加强抗菌药物临床应用管理的通知》为指导加强管理后,骨科围手术期抗菌药物临床应用情况。[方法]对2008年6月份28例和2009年6月份32例骨科I、II类切口手术患者进行调查分析。[结果]两组不同手术时期抗菌药物应用例数和术后感染率差异无统计学意义(P﹥0.05)。但与2008年组比较,2009年组抗菌药物应用种类明显不同(P﹤0.05),手术后预防用药时间明显缩短(P﹤0.05),抗菌药物联合使用率明显下降(P﹤0.05)。[结论]强化管理后,抗菌药物临床应用取得一定效果,但也存在不足,有待于进一步规范。
[Objective] To observe the clinical application of orthopedic perioperative antibacterials under the guidance of “Guiding Principles of Clinical Application of Antibacterial Drugs” and “Notice of the General Office of the Ministry of Health on Further Strengthening the Management of Clinical Application of Antibacterial Drugs”. [Methods] 28 cases of June 2008 and June 2009 32 cases of orthopedics I, II incision surgery patients were analyzed. [Results] There was no significant difference in the number of antibacterials and postoperative infection rates between the two groups (P> 0.05). However, compared with 2008 group, the application of antimicrobial agents in 2009 group was significantly different (P <0.05), the time of prophylaxis after operation was significantly shortened (P <0.05), and the combined use of antimicrobial agents was significantly decreased (P <0.05). [Conclusion] After intensive management, the clinical application of antibacterials has achieved some results, but there are still some shortcomings, which need to be further regulated.