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传统观点认为,在肿瘤的血行转移中,血管内皮细胞仅起一个“防护屏障”的作用。直到80年代,随着体外血管内皮细胞培养体系的建立和研究,人们才对血管内皮细胞在肿瘤血行转移中的作用有了新的认识。血循环中的肿瘤细胞,要穿过血管壁,进入血管外组织形成转移灶,第一步必须尽快地粘附到血管内壁上。只有牢固地粘附在血管内壁上的肿瘤细胞,才具有进一步穿过血管壁、继续生长繁殖形成转移灶的生命力,否则,在血循环中不能摄取营养而很快死亡。因此,肿瘤细胞与血管内壁的粘附,是肿瘤完成血行转移的关键的第一步。本文就肿瘤细胞与血管内皮细胞间粘附在肿瘤血行转移中的作用,着
The traditional view is that vascular endothelial cells only act as a “protective barrier” in the blood metastasis of tumors. Until the 1980s, with the establishment and study of in vitro vascular endothelial cell culture system, people had a new understanding of the role of vascular endothelial cells in tumor blood metastasis. The tumor cells in the blood circulation must pass through the blood vessel wall and enter the extravascular tissue to form a metastasis. The first step must adhere to the inner wall of the blood vessel as soon as possible. Only the tumor cells firmly adhering to the inner wall of the blood vessel have the vitality to further penetrate the wall of the blood vessel and continue to grow and multiply to form a metastasis. Otherwise, they cannot absorb the nutrients and die quickly in the blood circulation. Therefore, the adhesion of tumor cells to the inner wall of the blood vessel is the key first step in the complete blood transfer of the tumor. The role of adhesion between tumor cells and vascular endothelial cells in metastasis of tumor blood is discussed in this paper.