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检测急性乙肝14例,慢性乙肝59例,无症状HBsAg携带者10例的血清抑制因子(SIF)的活性。慢肝活动期SIF活性最高,急性乙肝次之。慢肝非活动期和无症状携带者的血清常测不出SIF,相反对正常人的淋巴细胞增殖反应有增强作用。SIF的活性强度与血清的病毒抗原和病毒核酸的浓度有关,机体内病毒量的增减决定了SIF值的变化,部分慢肝病人的SIF出现持续状态很可能是病毒在体内持续存在和不断复制的原因所致。慢乙肝中多次测到高活性的SIF提示病情有向重症肝炎发展的倾向。
The serum levels of SIF were measured in 14 patients with acute hepatitis B, 59 with chronic hepatitis B and 10 with asymptomatic HBsAg carriers. Slow activity of SIF activity of the highest liver, followed by acute hepatitis B. Slow inactive sera and asymptomatic carriers of the serum can not always detect SIF, on the contrary, normal lymphocyte proliferation response enhanced. The activity of SIF is related to the serum concentration of viral antigens and viral nucleic acids. The increase or decrease of the amount of the virus in the body determines the change of SIF value. The persistence of the SIF in some chronic liver disease patients is likely to persist and replicate in vivo Due to the reasons. Slowly measured in many chronic hepatitis B high activity of SIF tips the disease has the tendency to develop severe hepatitis.