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为了建立急性心肌梗塞动物模型 ,2 0只实验兔于无菌条件下开胸结扎冠状动脉左前降支 (LAD) ,并观察心电图 (ECG)、血清心肌酶及其同工酶的变化 .结果 :术前描记心电图均正常 ;结扎LAD即刻有 7只 ,30min后有 9只兔可见ST段抬高 ,心电图呈现动态变化 ;结扎LAD后 2h有 2只兔心肌梗塞图形不典型 ,2只术中死亡 ;术后 4周 18只兔心电图描记均可见胸导联有病理性Q波 .结扎LAD后 2 4h ,血清心肌酶AST ,LDH ,LDH - 1,CK ,CK -MB明显升高 ,与术前比较 (除LDH外 )均有显著差异 (P <0 0 1) .结果表明 :该法操作简单 ,重复性好 ,形成梗塞可靠 ,术后可长期饲养 ,为临床冠心病的实验研究提供了一个有价值的动物模型 .
In order to establish an animal model of acute myocardial infarction, 20 rabbits underwent thoracotomy on the left anterior descending coronary artery (LAD) under aseptic conditions and observed the changes of electrocardiogram (ECG), serum myocardial enzymes and their isoenzymes.Results: The preoperative electrocardiogram was normal. Seven LADs were ligated immediately, ST segment elevation was observed in nine rabbits after 30min, and the electrocardiogram showed dynamic changes. Two rabbits with LAD were not typical at 2h, and 2 died during operation At 4 weeks after operation, ECG of thoracic aorta showed pathological Q-waves in 18 rabbits, and the serum levels of AST, LDH, LDH-1, CK and CK-MB were significantly increased 24 h after ligation of LAD, (Except LDH) were significantly different (P <0.01) .The results showed that: The method is simple, good repeatability, the formation of a reliable infarction, postoperative long-term feeding, providing an experimental study of clinical coronary heart disease Valuable animal model.