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体外循环对机体的正常生理功能有明显的影响。体外循环所带来的病理生理变化,对药物的作用也将产生一定的影响。一、药物学的基本原理: 药物要起作用必须在其发生作用的部位达到一定浓度才有效。这与药物的摄取、分布与排泄有关,另还与给以一定量的药物后药物在作用部位浓度的变化有关。在药物作用的部位浓度的变化受一些因素和条件的影
Cardiopulmonary bypass on the body’s normal physiological function have a significant impact. The pathophysiological changes caused by cardiopulmonary bypass, the role of drugs will also have a certain impact. First, the basic principles of pharmacology: Drugs to play a role must be in the role of the site to reach a certain concentration was effective. This is related to the uptake, distribution and excretion of the drug, and also to the change in the concentration of the drug at the site of action given a certain amount of the drug. Changes in the concentration of the drug action site by a number of factors and conditions