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目的和方法：通过体外孵育试验，研究胃泌素和生长抑素对十二指肠和十二指肠溃疡（Ｄｕ）旁粘膜表皮生长因子（ＥＧＦ）含量的影响。结果：活动期Ｄｕ旁粘膜ＥＧＦ含量减少，愈合期含量增高。五肽胃泌素可显著增加粘膜ＥＧＦ含量；生长抑素类似物奥曲肽可减少愈合期Ｄｕ旁粘膜ＥＧＦ含量，并有抑制五肽胃泌素增加ＥＧＦ含量的作用。结论：十二指肠粘膜ＥＧＦ含量减少可能是Ｄｕ的发病因素之一；胃泌素可刺激十二指肠粘膜ＥＧＦ合成，而生长抑素可抑制胃泌素的作用
Objective: To investigate the effect of gastrin and somatostatin on epidermal growth factor (EGF) in mucosa of duodenum and duodenal ulcer in vitro by in vitro incubation. Results: During the active Du phase mucosal EGF content decreased, the healing period increased. Pentagonal gastrin can significantly increase the EGF content of mucosa; somatostatin analogue octreotide can reduce the healing Du phase mucosal EGF content, and inhibition of pentagastrin increased EGF content. Conclusions: The decrease of EGF content in duodenal mucosa may be one of the risk factors for Du. Gastrin may stimulate EGF synthesis in duodenal mucosa, while somatostatin may inhibit the effect of gastrin