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目的探讨新辅助化学疗法(化疗)对结直肠癌手术患者炎症因子水平的影响。方法回顾2008年1月-2009年12月诊断为结直肠癌的487例患者的临床资料,剔除不符合研究条件者后,共390例,以是否接受过新辅助化疗分为术前化疗组(化疗组)156例与对照组234例进行研究。分别比较两组在入院时、术前、术后的炎症因子水平。结果入院时两组外周血白细胞、C反应蛋白(CRP)、纤维蛋白原、血清淀粉样蛋白水平差异均无统计学意义(P>0.05);术后化疗组CRP水平[(64.09±60.24)mg/L]低于对照组[(87.80±61.54)mg/L],差异有统计学意义(P<0.05);其余炎症因子组间差异无统计学意义(P>0.05)。结论新辅助化疗不会刺激机体产生免疫反应,且有一定的安全性。
Objective To investigate the effect of neoadjuvant chemotherapy (chemotherapy) on inflammatory cytokines in colorectal cancer patients. Methods The clinical data of 487 patients diagnosed with colorectal cancer from January 2008 to December 2009 were retrospectively analyzed. Among the 390 patients who did not meet the study criteria, 390 patients were divided into preoperative chemotherapy group (n = Chemotherapy group) 156 cases and control group 234 cases were studied. The levels of inflammatory cytokines in the two groups were compared before and after admission. Results There were no significant differences in peripheral blood leukocytes, C-reactive protein (CRP), fibrinogen and serum amyloid level between the two groups on admission (P> 0.05). CRP levels in the postoperative chemotherapy group were (64.09 ± 60.24) mg / L] was lower than that of the control group [(87.80 ± 61.54) mg / L], the difference was statistically significant (P <0.05). There was no significant difference among the other inflammatory factors (P> 0.05). Conclusion Neoadjuvant chemotherapy does not stimulate the body to produce immune response, and has some safety.