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前列腺特异抗原(PSA)是一种血管舒缓素样的丝氨酸水解酶,只有前列腺组织(不论其为良性抑恶性)能产生这种抗原,在生理情况下,精囊液含有高浓度的PAA,它能把精囊内的高分子蛋白分解为小分子的多肽,使凝块水解,血清内也含有PSA,且可用单克隆或多克隆放射免疫方法准确测定,血清PSA的半衰期为2.2～3.2天,肛门指检,膀胱镜检和前列腺穿刺活检都可使血清PSA浓度升高,细菌性前列腺炎和急性尿潴留也可使其浓度升高,应注意鉴别。前列腺增生(BPH)病人中有25%血清PSA高于正常值,因此PSA不能单独用来作为早期前列腺癌
Prostate-specific antigen (PSA) is a kallikrein-like serine hydrolase, and only the prostate tissue (whether benign or malignant) can produce this antigen. Under physiological conditions, seminal fluid contains high concentrations of PAA, which can The macromolecule protein in the seminal vesicle is decomposed into small molecule polypeptides that hydrolyze the clot and the serum also contains PSA, and can be accurately determined by monoclonal or polyclonal radioimmunoassay. The half-life of serum PSA is 2.2 to 3.2 days, and the anal finger Examination, cystoscopy and prostate biopsy can increase serum PSA concentration. Bacterial prostatitis and acute urinary retention can also increase its concentration. Attention should be paid to identification. 25% of patients with benign prostatic hyperplasia (BPH) have higher than normal serum PSA, so PSA cannot be used alone as early prostate cancer