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矽肺和肺癌之间的关系早已引起人们的注意。有人报告矽肺病人的肺癌发生率比非矽肺病人肺癌发生率高10倍。推测这可能与二氧化硅粉尘在肺组织内吸附和贮存致癌物质有关。但也有的学者指出,二氧化硅粉尘促进肺肿瘤发生的理由还不充分。本文通过动物实验研究,试图证明二氧化硅粉尘有促进苯并茈引起大鼠肺肿瘤的作用。 材料与方法:用225只体重在100克左右的大鼠,共分四组。Ⅰ组—58只大鼠(♀30只,(?)28只)气管内注入含有5毫克苯并茈和50毫克石英粉尘的混悬液;Ⅱ组—70只大鼠,(♀33只,(?)37只)气管内注入50毫克石英粉尘,经4个月后注入5毫克苯并茈;Ⅲ组——28只大鼠(♀18只,(?)10只)仅注5毫克苯并茈;Ⅳ组——对照组——69只大鼠(♀33只,(?)39只)未注任何物质。石英粉尘粒子82％在2微
The relationship between silicosis and lung cancer has long drawn people’s attention. It has been reported that the incidence of lung cancer in patients with silicosis than non-silicosis patients with lung cancer 10 times higher incidence. Presumably this may be related to silica dust adsorption and storage of carcinogens in the lung tissue. However, some scholars pointed out that the reason that silica dust promotes the development of lung tumors is not sufficient. In this paper, animal experiments to try to prove that silica dust can promote benzodiazepine induced lung tumor in rats. Materials and Methods: 225 rats weighing about 100 grams were divided into four groups. Rats in Group I -58 (♀30,? 28) were injected intratracheally with a suspension containing 5 mg of benzathine and 50 mg of quartz dust; Group II-70 rats (♀ 33, (?) 37) intratracheal injection of 50 mg of quartz dust, 4 mg after injection of 5 mg of benzoguanidine; Group Ⅲ - 28 rats (♀ 18, (? And 茈; Ⅳ group - control group - 69 rats (♀33 only, (?) 39) did not note any substance. Quartz dust particles 82% in 2 micro