流感病毒是重要的呼吸道传染病病原体，可引起季节性流感流行和全球性流感大暴发，对公共卫生造成严重威胁。流感病毒对宿主的致病性取决于病毒毒力及其对宿主的免疫逃逸，本文概述了流感病毒逃避宿主先天免疫反应和适应性免疫反应的各种策略，以及相关机制的最新研究进展。对流感病毒免疫逃逸的深入研究，将有助于了解病毒与宿主之间的相互作用，阐明流感病毒致病机制，为抗流感病毒药物的研发提供新策略。“,”Influenza is a contagious respiratory illness caused by influenza viruses that can result in seasonal epidemics and global influenza pandemic, which poses a serious public health challenges world-wide. The pathogenicity of influenza virus depends to a great extent on viral virulence and its immune escape. This review provides an overview of the current understanding for the mechanisms by which influenza viruses to escape the host′s immune response, which will facilitate the future studies on influenza pathogenesis and the development of anti-influenza therapeutics.