1955年 Bateman〔1〕首先报道噻替哌局部化疗对多种恶性肿瘤有效。Johnes等也报道膀胱内灌注噻替哌可以治愈残留移行细胞癌并明显降低肿瘤复发的危险〔2〕。此后许多研究都肯定了膀胱内灌注化疗治疗膀胱癌的疗效。然而 ,最近长期随访的随机资料显示膀胱灌注化疗不能降低长期后 1955 Bateman 〔1〕 first reported thiatriptifen local chemotherapy for a variety of malignant tumors. Johnes et al. Also reported that intratracheal instillation of thilotlap could cure residual transitional cell carcinoma and significantly reduce the risk of tumor recurrence (2). Since then, many studies have confirmed the efficacy of intravesical chemotherapy in the treatment of bladder cancer. However, recent randomized long-term follow-up data showed that chemotherapy with bladder infusion failed to reduce long-term outcomes