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目的通过监测非小细胞肺癌(non-small cell lung cancer,NSCLC)患者放射治疗前后血清胰岛素样生长因子结合蛋白-3(IGFBP-3)的表达,探讨其在非小细胞肺癌诊疗及预后中的临床意义。方法运用ELISA检测62例非小细胞肺癌患者(观察组)放射治疗前后外周血清IGFBP-3水平,与62例肺部无病变者(对照组)治疗前后外周血血清中IGFBP-3的水平进行比较,并总结分析其中的变化差异。结果观察组与对照组放疗前血清IGF-1比较差异有统计学意义(P<0.01),观察组放疗后血清IGFBP-3表达显著低于对照组,差异有统计学意义(P<0.05),两组患者放疗前血清IGFBP-3表达差异无统计学意义(P>0.05),62例观察组患者有效组中IGF-1放疗前后差异有统计学意义(P<0.01)。结论非小细胞肺癌患者血清IGFBP-3表达在非小细胞肺癌的发生、发展及远处转移过程中有重要意义。监测其水平变化是非小细胞肺癌的诊断及判断其预后的有意义指标。
Objective To investigate the expression of insulin-like growth factor-binding protein-3 (IGFBP-3) in patients with non-small cell lung cancer (NSCLC) before and after radiotherapy and to explore its role in the diagnosis and prognosis of non-small cell lung cancer Clinical significance. Methods The serum levels of IGFBP-3 in peripheral blood of 62 non-small cell lung cancer patients (observation group) before and after radiotherapy were detected by ELISA. The levels of IGFBP-3 in serum of 62 non-pulmonary lesion patients (control group) before and after treatment were compared , And summarizes and analyzes the changes among them. Results The serum IGF-1 level in observation group and control group before radiotherapy were significantly different (P <0.01). The serum IGFBP-3 expression in observation group was significantly lower than that in control group after radiotherapy (P <0.05) There was no significant difference in serum IGFBP-3 expression between the two groups before and after radiotherapy (P> 0.05). There was significant difference between the two groups before and after radiotherapy (P <0.01). Conclusion Serum IGFBP-3 expression in patients with non-small cell lung cancer is of great importance in the development, progression and distant metastasis of non-small cell lung cancer. Monitoring the level of change is a meaningful indicator of the diagnosis of non-small cell lung cancer and its prognosis.