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粪便血红素定量(Hcom Quant)测定是一种测定粪便隐血的新方法。它是测定粪便中卟啉的含量。本文介绍这一检测方法。318例正常人在不限制饮食的条件下,进行粪便邻甲氧基苯酚法和Homo Quant测定对比,测出正常人粪便中血红素为21.62±10.81μg/g粪,>42μg/g粪有肯定意义。通过线性试验、重复试验和回收试验确证检测方法是可信的。还对40例非胃肠肿瘤和34例胃肠道癌肿患者的粪便,以邻甲氧基苯酚法、反向间接血凝法(RPHA)和Hcmo Quant法测定法进行比较,在胃肠道癌肿病例中邻甲氧基苯酚法阳性率41%,RPHA法53%,Hcmo Quant法74%。在非胃肠道肿瘤病例中,邻甲氧基苯酚法无一例阳性,RPHA法的假阳性率为22.5%,Hcmo Quant测定12.5%>42μg/g粪。结果初步表明Hcmo Quant测定比其它隐血试验敏感和特异,值得推广使用。
The stool heme quantitation (Hcom Quant) assay is a new method for determining fecal occult blood. It is the determination of stool in the porphyrin content. This article describes this test method. 318 cases of normal people without restriction on diet conditions, the determination of methoxyphenol method and Homo Quant mannitol, normal fecal hematin was measured 21.62 ± 10.81μg / g faeces,> 42μg / g faecal affirmation significance. It is credible to confirm the test by linear test, repeat test and recovery test. The stool samples of 40 patients with non-gastrointestinal tumors and 34 patients with gastrointestinal cancers were also compared by o-methoxyphenol method, reverse-indirect hemagglutination (RPHA) and Hcmo-Quant assay, In the cancer cases, the methoxyphenol positive rate was 41%, RPHA 53% and Hcmo Quant 74%. In non-gastrointestinal cancer cases, none of the o-methoxyphenols was positive, with a false-positive rate of 22.5% for RPHA and 12.5%> 42 μg / g for Hcmo Quant. Preliminary results show that the Hcmo Quant assay is more sensitive and specific than other occult blood tests and is worth promoting.