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血管内皮细胞在血管构筑、基底膜更新修复以及肿瘤组织内的血管生长调控中起重要作用。为进一步了解Ⅳ型胶原酶与内皮细胞、血管外间质之间的相互关系,本文用体外培养的内皮细胞作免疫细胞化学染色,观察内皮细胞表面Ⅳ型胶原酶分布与表达。研究结果表明,人血管内皮细胞具有合成和表达Ⅳ型胶原酶的功能,并对此作了进一步的讨论。
Vascular endothelial cells play an important role in the construction of blood vessels, the regeneration and repair of basement membrane, and the regulation of blood vessel growth in tumor tissues. In order to further understand the relationship between type IV collagenase and endothelial cells and extravascular extracellular matrix, the endothelial cells in vitro were used for immunocytochemical staining to observe the distribution and expression of type IV collagenase on the surface of endothelial cells. The results show that human vascular endothelial cells have the function of synthesizing and expressing type IV collagenase, and further discussed.