论文部分内容阅读
目的观察异甘草酸镁治疗类风湿关节炎(RA)伴肝功能异常的临床疗效。方法 RA合并肝功能异常患者64例随机均分为两组,分别采用异甘草酸镁(试验组)和还原型谷胱甘肽(对照组)治疗;疗程均为2周,比较两组临床疗效和不良反应发生情况。结果试验组总有效率高于对照组(96.9%vs.84.4%)(P<0.05)。治疗1、2周后,两组ALT、AST、TBil、ALP和γ-谷氨酰基转移酶(GGT)均较治疗前下降(P<0.05)。治疗1、2周后,试验组ALT、AST、GGT和ALP较对照组下降更显著(P<0.05)。两组患者均未发生严重不良反应。结论与还原型谷胱甘肽比较,异甘草酸镁治疗更能有效改善RA患者的肝功能。
Objective To observe the clinical efficacy of magnesium isoglycyrrhizinate in the treatment of rheumatoid arthritis (RA) with liver dysfunction. Methods Sixty-four patients with RA and liver dysfunction were randomly divided into two groups and treated with magnesium isoglycyrrhizinate (experimental group) and glutathione (control group) respectively for two weeks. The clinical efficacy and adverse reactions What happened? Results The total effective rate of the experimental group was higher than that of the control group (96.9% vs. 84.4%) (P <0.05). After 1 and 2 weeks of treatment, ALT, AST, TBil, ALP and γ-glutamyl transferase (GGT) in both groups were significantly lower than those before treatment (P <0.05). After treatment for 1 and 2 weeks, ALT, AST, GGT and ALP in the experimental group decreased more significantly than those in the control group (P <0.05). No serious adverse reactions occurred in both groups. Conclusion Compared with reduced glutathione, magnesium isrimazide treatment is more effective in improving liver function in RA patients.