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目的探讨卡维地洛对老年慢性心力衰竭患者Th1/Th2细胞因子比率变化的影响。方法选择老年慢性心力衰竭患者200例,随机分为对照组和治疗组,每组100例。同时选择健康体检者50例为正常对照组。对照组给予呋塞米、血管紧张素转换酶抑制剂及洋地黄治疗,治疗组在对照组基础上给予卡维地洛治疗。采用酶联免疫吸附法测定外周血Th1类细胞因子(IFN-γ)和Th2类细胞因子(IL-10)水平。结果与正常对照组相比,对照组和治疗组IFN-γ、IFN-γ/IL-10明显升高,IL-10水平明显下降,差异均有统计学意义(P<0.05);与对照组治疗后相比,卡维地洛组治疗后患者IFN-γ、IFN-γ/IL-10明显下降,IL-10水平明显升高,差异均有统计学意义(P<0.05)。结论老年慢性心力衰竭患者Th1/Th2类细胞因子失衡,卡维地洛可调节炎性细胞因子的释放,恢复Th1/Th2类细胞因子的平衡,调节免疫功能,改善心功能。
Objective To investigate the effect of carvedilol on the Th1 / Th2 cytokine ratio in elderly patients with chronic heart failure. Methods 200 elderly patients with chronic heart failure were randomly divided into control group and treatment group, 100 cases in each group. At the same time, 50 healthy people were selected as normal control group. Control group was given furosemide, angiotensin converting enzyme inhibitors and digitalis treatment, the treatment group was given carvedilol on the basis of the control group. Peripheral blood levels of Th1 cytokines (IFN-γ) and Th2 cytokines (IL-10) were measured by enzyme-linked immunosorbent assay. Results Compared with the normal control group, the levels of IFN-γ and IFN-γ / IL-10 in the control group and the treatment group were significantly increased and the levels of IL-10 were significantly decreased (P <0.05) After treatment, the levels of IFN-γ, IFN-γ / IL-10 and the levels of IL-10 in the carvedilol group were significantly decreased after treatment (P <0.05). Conclusions Th1 / Th2 cytokines are imbalanced in elderly patients with chronic heart failure. Carvedilol may regulate the release of inflammatory cytokines, restore the balance of Th1 / Th2 cytokines, regulate immune function and improve cardiac function.