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如何确定动物慢性中毒实验的观察期限,迄今尚无严格的科学依据.有人提出哺乳动物的寿命与体重呈直线相关,但人的情况例外.研究表明,由哺乳动物最重要的生理指标推导出来的“种属稳定性参数”是评定物质生物作用慢性实验观察期限的最佳依据,而且可参照各种动物的长寿界限.种属长寿界限不同于平均寿命,前者取决于机体的生物学可能性,而后者受病理状况影响.
There is no strict scientific basis for how to determine the observation period for chronic poisoning experiments in animals, but it has been suggested that there is a linear correlation between mammalian life expectancy and body weight, except in the case of humans, which have been derived from the most important physiological indices of mammals “Species stability parameters ” is the best basis for the evaluation of the chronic experimental observation of the role of material organisms, and may refer to the longevity limits of various animals .Longevity limits of species is different from the average life expectancy, the former depends on the biological potential of the body Sex, which is affected by the pathological conditions.