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从疟原虫的不同发育时期、不同的疫苗成份和宿主的遗传基因限制性等方面 ,深入研究抗疟疾疫苗 .作用于红细胞前期的疟疾疫苗主要是抑制疟疾的临床发作 ,控制疟疾的传播 ;作用于红细胞期的疟疾疫苗诱导宿主体液免疫系统 ,产生特异性抗体 ,抑制疟原虫侵入和感染红细胞 ,达到减少疟原虫虫荷 ,降低疟疾的发病率和死亡率 .作用于疟原虫有性生殖时期 ,控制疟疾传播的疟疾疫苗 ,其意义在于控制一个地区疟原虫的感染率和疟疾发病率 ,但对已感染疟原虫个体的免疫保护作用意义不大 .在设计疟疾疫苗的过程中 ,必须克服不同个体的遗传基因限制性问题 .由于疟原虫生活史的复杂性 ,同时也必须考虑到疟原虫不同发育阶段抗原成份的复杂性 .
From the different developmental stages of Plasmodium, different vaccine components and host genetic limitations and other aspects, in-depth study of anti-malarial vaccine role in pre-erythrocytic malaria vaccine is mainly to inhibit the clinical malaria attack, control of malaria transmission; role in The erythrocytic malaria vaccine induces host humoral immune system, produces specific antibodies, inhibits the invasion of Plasmodium and infects erythrocytes, reduces the burden of malaria parasites, and reduces the incidence and mortality of malaria. In the period of sexual reproduction of Plasmodium, control The malaria-transmitted malaria vaccine has the significance of controlling the incidence of malaria parasites and the incidence of malaria in one area, but not for the immune protection of individuals already infected with malaria parasites. In the design of a malaria vaccine, Due to the complexity of the life cycle of the Plasmodium, the complexity of the antigenic components at different developmental stages of Plasmodium must also be considered.