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目的:观察中药益糖康干预并有并有糖调节受损的代谢综合征的临床疗效。方法:通过对患者空腹血糖(fasting plasma glucose,FPG)、餐后2h血糖(2 hours plasma glucose;postprandial blood glucose;2hPG,PBG)、糖化血红蛋白(HbAlc)、体重(body weight,BW)、总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白(high density lipoprotein,HDL-C)、低密度脂蛋白(low density lipoprotein,LDL-C)等主要指标进行分析。结果:①中药益糖康组FPG降低,与西药组(二甲双胍)相比,具有显著差异(P<0.05)。②中药益糖康组HbAlc、2hPG降低,与西药组(二甲双胍)相比,无显著差异(P>0.05)。③1年后中药益糖康组患者HbAlc较基线下降(P<0.005)。④1年后中药益糖康组患者的血脂谱与基线相比:TG下降16%(P<0.005),TC下降10%(P<0.005),LDL-C下降8%(P<0.0001),而HDL-C升高24%(P<0.0001)。⑤患者FPG每下降0.8mmol/L,BW平均下降0.9kg,与西药组(二甲双胍)相比,具有显著差异(P<0.005)。结论:中药益糖康可降糖、减轻体重,改善血脂谱,具有潜在的心血管收益。
Objective: To observe the clinical efficacy of traditional Chinese medicine Yi Tang Kang intervention and metabolic syndrome with impaired glucose regulation. Methods: The fasting plasma glucose (FPG), postprandial blood glucose (2hPG, PBG), HbAlc, body weight (BW), total cholesterol total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C) and low density lipoprotein (LDL-C) were analyzed. Results: ① FPG decreased in traditional Chinese medicine Yixikang group, which was significantly different from western medicine group (metformin) (P <0.05). ② HbAlc, 2hPG decreased in traditional Chinese medicine Yixikang group compared with Western medicine group (metformin), there was no significant difference (P> 0.05). ③ After 1 year, the HbAlc in Chinese medicine Yixikang Decline was lower than that in the baseline (P <0.005). (1) After 1 year, the lipid profile of the Chinese medicine Yixikang group showed a 16% decrease in TG (P <0.005), a 10% decrease in TC (P <0.005) and a 8% decrease in LDL-C (P <0.0001) HDL-C increased by 24% (P <0.0001). ⑤The FPG decreased 0.8mmol / L and BW decreased by 0.9kg in average, which was significantly different from that of western medicine group (P <0.005). Conclusion: Yi Tang Kang Chinese medicine can be hypoglycemic, reduce weight, improve blood lipid profile, with potential cardiovascular benefits.