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白鲜皮(Dictamnus dasycarpus Turcz.的根皮)是我国传统中药,70年代曾有报导表明白鲜皮具有抗菌(包括抗结核菌),抗肿瘤活性。本文报导了依据伊红染色试验确认其非极性提取物具有体外抗癌活性,并从其乙醚提取物和其挥发油部分共分离得到九个化合物。根据其理化性质和光谱分析鉴定了其中的五个化合物——梣酮(Fraxinellone)(也得自其挥发油中),β-谷甾醇,白鲜碱(Dictamine),黄柏酮(Obacunone),和柠檬苦素(Linionin)。药理实验表明梣酮,白鲜碱和得自挥发油的一种无色透明液体(化合物I)具有体外抗癌活性。
White fresh skin (Dictamnus dasycarpus Turcz. root bark) is a traditional Chinese medicine. In the 1970s, it was reported that white fresh skin has antibacterial (including antituberculosis) and anti-tumor activity. This paper reports that the non-polar extracts have in vitro anticancer activity based on the eosin staining test, and nine compounds were co-isolated from their ether extracts and their volatile oil fractions. Based on the physicochemical properties and spectral analysis, five of them were identified: Fraxinellone (also from its volatile oil), β-sitosterol, Dictamine, Obacunone, and lemon. Linionin. Pharmacological experiments showed that fluorenone, diterpenoid and a colorless, transparent liquid (compound I) from volatile oil had in vitro anticancer activity.